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Corneal topography may show a "crab claw-like" appearance, a finding that is seen in both keratoconus and in pellucid marginal degeneration. However, it may not be as specific as corneal pachymetry, because corneal topography only evaluates the degree and distribution of surface irregularities on the cornea, not the thickness of the cornea. The gold standard diagnostic test for PMD is corneal topography. PMD lacks apical corneal scarring, Rizutti's phenomenon, Munson's sign, and the central corneal thickness is usually normal. The inferior peripheral thinning is seen between the 4 o'clock and 8 o'clock positions. In PMD we can see high against the rule astigmatism along with horizontal bow ties. The portion of the cornea that is immediately adjacent to the limbus is spared, usually a strip of about 1–2 mm. The center of the cornea shows normal thickness, with an intact central epithelium, but the inferior cornea exhibits a peripheral band of thinning, to about 1–2 mm. The Bowman's layer of the cornea may be absent, irregular, or have ruptured areas. There may be an increase in the number of mucopolysaccharides in the corneal stroma. The thinning of the corneas may approach 20% of normal thickness. PMD is an idiopathic, non-inflammatory condition. Normally, PMD does not present with vascularization of the cornea, scarring, or any deposits of lipid. This is described as a "beer belly" appearance since the greatest protrusion occurs below the horizontal midline (unlike keratoconus). The cornea just above the region of thinning is of normal thickness, and may protrude anteriorly, which creates an irregular astigmatism. The distribution of the degeneration is crescent or arcuate shaped. PMD is characterized by bilateral thinning ( ectasia) in the inferior and peripheral region of the cornea. While PMD usually affects both eyes, some unilateral cases have been reported. However, in rare cases, PMD may present with sudden onset vision loss and excruciating eye pain, which occurs if the thinning of the cornea leads to perforation. Pain is not typically present in pellucid marginal degeneration, and aside from vision loss, no symptoms accompany the condition. The condition is rare, though the exact prevalence and incidence are unknown. The word "pellucid" means clear, indicating that the corneas retain clarity in pellucid marginal degeneration. The term "pellucid marginal degeneration" was first coined in 1957 by the ophthalmologist Schalaeppi. Surgery is reserved for individuals who do not tolerate contact lenses. Intacs implants, corneal collagen cross-linking, and corneal transplant surgery are additional options. Treatment usually consists of vision correction with eyeglasses or contact lenses. Corneal pachymetry may be useful in confirming the diagnosis. Pellucid marginal degeneration is diagnosed by corneal topography. The cause of the disease remains unclear. It is typically characterized by a clear, bilateral thinning ( ectasia) in the inferior and peripheral region of the cornea, although some cases affect only one eye. Rarely, it may cause acute vision loss with severe pain due to perforation of the cornea. It typically presents with painless vision loss affecting both eyes. Pellucid marginal degeneration ( PMD) is a degenerative corneal condition, often confused with keratoconus. Vision correction ( eyeglasses or contact lenses) Pellucid corneal degeneration with hydrops and detachment of Descemet's membrane Medical condition Pellucid marginal degeneration
If you have any information relating to these unsolved crimes, contact the Metropolitan Police Department at (202) 727-9099. The all new series premieres on May 17, 2023. You can listen to all six episodes wherever you get your podcasts. Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Headlee will ask the questions: Why didn’t these murders make the news headlines? Did law enforcement do enough to solve these crimes? And how do racial disparities impact these types of investigations, past and present? Plus, we’ll explore new evidence which may crack the cold case wide open again. Great to see Datelines newest original podcast series at the top of Apples charts. Journalist and Public Radio veteran Celeste Headlee (NPR, PBS, TEDx) examines old case files and interviews the investigators and family members who are still haunted by these killings. While on a romantic vacation with their partner, Jody Scharf finds herself falling. Its the Part 1 of the podcast about the 5th Dateline episode on the case. This episode’s story concerns one woman’s fall from the edge of a cliff. Floridas best man and Datelines own Dennis Murphy returns with a case as. Having someone hanging just short of oblivion reminds us why we fear heights the way we do. Kimberly and Katie - ADWDL Episodes Killing Time S.31 Ep.30 Along Came Sarah S.31 Ep.29 Special Guest: JOSH MANKIEWICZ on Justice for Kristin Smart/ Behind. The media dubbed him “The Freeway Phantom.”įrom iHeartRadio and Tenderfoot TV, a new podcast reinvestigates the 50 year old unsolved murders of these young girls. The ‘Cliffhanger’ is one of the oldest literary devices in the book. Follow now to get the latest episodes of Murder & Magnolias each week completely free, or subscribe to Dateline Premium on Apple Podcasts. In Dateline’s latest podcast, Keith Morrison takes us to the Low Country of South Carolina to tell the twisted tale. Their bodies were discarded alongside DC freeways. But when a hit man targets one of them, a story of betrayal and murderous intent unfolds. Just wish Chris and her would tell the truth.Between 19, six black girls went missing in the Washington D.C. I’m so heartened to hear that the other dude got sober and that was the key to success for him.Īlso interesting the difference in the two parties interpretation of “God” Watching it on TV normalizes what is textbook pathological codependent, addictive, and abusive behavior. Dateline’s ‘Missing in America’ posted about Erin’s disappearance. It was dark when the killer shut off the engine, he says. Her husband reported her missing on Sunday, June 29. The podcast begins with the sound of a car slowing down, and then a straight-talking narrator takes over. Because I think there are folks watching who maybe are in a similar relationship or know others that are and don’t know what they are looking at. Erin was three months pregnant at the time and the wife of a marine. I must say I wish that when they portray this kind of thing on Dateline, that they would also have a professional mental health expert or psychologist to give some context to what we are watching. What a small God she must have to end up with the short end of the stick is what strikes me. Interesting that Wendy’s talk of her “amazing” and life-long relationship with God is non-existent at the end of the last episode when she whines “it’s not fair….” A daily True Crime, News and Society podcast featuring Keith Morrison and Lester Holt. (I’m not very tech savvy and I don’t know how to reverse it on my phone.According to Men’s Health, the act itself, now with straight men as the willing recipients, has been rebranded with a new name. There’s a time and place for everything, and I guess tonight wasn’t it. And I didn’t feel aroused enough so I didn’t want him to touch me without my underwear because the setting wasn’t right. The cold did not turn me on - it did the opposite. Thing is, we were outside and it was really, really cold. He (with my consent, of course) tried the whole rubbing my vagina through my underwear. It was exciting when he unzipped my jacket and touched my thighs and stuff. Hel wrote:Update: So he and I were out tonight, and he asked if I wanted to try the whole fingering thing. Though it was a (mostly) unsuccessful attempt at fingering, I’m still glad he and I are going to try again until we get it right, and that we can talk openly about sex and sexual stuff. Any tips on how I should touch him? I’ll ask him too, obviously, but I don’t have experience with this so I wondered if there were general tips to make it enjoyable for both of us. We decided to wait on that as well so we could both be more aroused - hopefully that will make the experience better. How can I be more turned on?Īlso, he asked me if I wanted to touch his penis and I wasn’t sure - I told him I hadn’t given it much thought. I was a bit disappointed because I wasn’t horny enough to really feel anything when he was touching me down there. I’m hoping that since it will be warmer (and we’ll have more time to be together) I’ll be able to get more aroused and wet. I really want to get aroused! We have the chance to be inside next weekend, so we’re planning on trying again then. Update: So he and I were out tonight, and he asked if I wanted to try the whole fingering thing. That could be around body image - like how much looking or not looking you are okay with, and what you need around that - it could be about what you want from communication and consenting - would you like him to ask you about what he's going to do in a very step-by-step way or more generally? What else do you want from communication? - it could be about things like what you do first: maybe you want to do something first like take a bath together, or cuddle. You might also think about what you want and need from your partner to feel comfortable with all of this, and talk about that together. Since you masturbate, you already have some information from that and what you do to relax on your own that you can bring to this: what do you do to set the stage for yourself, as it were? How do you chill out in your body and mind before and during masturbation? That's often pretty individual, and depends a lot on what you find helps you to relax in general, and then sexually, and with this particular partner. I want this to be a really good experience and I just would like some tips on how to accomplish that. I'm nervous because I've never done this type of thing before but I'm really excited as well because I really trust my boyfriend and we have really good, open communication. Is this a realistic expectation?) Also, will this mean I'm not a virgin anymore, if we finger/masturbate each other? I'm hoping with him it will feel good though because I'll be more aroused. Will it hurt a lot if he puts his fingers inside my vagina? (I masturbate a lot but I've only managed to go inside myself a few times and it's been uncomfortable. He and I are both virgins and we've never touched each other's genitals before. I just have a lot of questions about what to expect. I'm actually looking forward to it a lot. However, I do want him to do it in the near future, so we agreed to do it later this week. He asked if he could finger/masturbate me too, and I said I wasn't ready for that tonight, since it was a lot to process. It's been really great so far - the conversations about sex, touching nipples, etc. So my boyfriend and I have started to talk about sex and be more sexual around each other. jQuery flip book image gallery plugin : jFlip. Sound Manager can be used with the jQuery plugin to add audio to the book. I'm also interested in using pdf.js and node.js for a new library that will convert pdf files into pure HTML5 (text/CSS3) files to provide content for the frontend with turn.js. The book’s pages can be set to turn when manually clicked only, begin auto flip (turn automatically) as soon as the html page loads, or begin auto flip when first page (front cover is clicked). Está definido como: Elemento para marcos. Sus etiquetas son:CD26 -/- mice have significantly higher values of IP-10 in serum and control skins compared with wild-type mice but values in wounds did not differ significantly on days 2, 4, and 7 of wound healing. CD26 deficiency induced prompt macrophage recruitment at the site of skin damage but did not influence mobilization of T-cells in comparison with wild-type mice. Obtained results revealed a better rate of wound closure, revascularization and cell proliferation in CD26 -/- mice, with enhanced local expression of hypoxia-inducible factor 1α and vascular endothelial growth factor. The process of cutaneous wound healing was monitored on defined time schedule postwounding by macroscopic, microscopic, and biochemical analyses. Experimental wounds were made on the dorsal part of CD26 deficient (CD26 -/- ) and wild-type mice (C57BL/6). The aim of this study was to investigate the process of wound healing in conditions of CD26 deficiency in order to obtain better insights on the role of DPP IV/CD26 in cutaneous regeneration. However, despite its known enzymatic and immunomodulative functions, limited data characterize the role of DPP IV/CD26 in cutaneous wound healing mechanisms. It has potential influence on different processes crucial for wound healing, including cell adhesion, migration, apoptosis, and extracellular matrix degradation. Involvement of DPP IV/CD26 in cutaneous wound healing process in mice.īaticic Pucar, Lara Pernjak Pugel, Ester Detel, Dijana Varljen, Jadrankaĭipeptidyl peptidase IV (DPP IV/CD26) is a widely distributed multifunctional protein that plays a significant role in different physiological as well as pathological processes having a broad spectrum of bioactive substrates and immunomodulative properties. Patients with R- IVCD constitute a subgroup of patients with a long Q-LV interval. Mid-QRS notching in lateral leads strongly predicts a longer Q-LV interval in L- IVCD patients. Patients with LBBB have a very prolonged Q-LV interval. The R- IVCD group presented an unexpectedly longer Q-LV interval (127.0 ± 12.5 ms 13/15 patients had Q-LV >110 ms). Isolated mid-QRS notching/slurring predicted Q-LV interval >110 ms in 68% of patients. Patients with LBBB presented a long Q-LV interval (147.7 ± 14.6 ms, all exceeding cutoff value of 110 ms), whereas RBBB patients presented a very short Q-LV interval (75.2 ± 16.3 ms, all 150 ms and intrinsicoid deflection >60 ms. The Q-LV interval in the different groups and the relationship between ECG parameters and the maximum Q-LV interval were analyzed. The IVCD group was further subdivided into 81 patients with left (L)- IVCD and 15 patients with right (R)- IVCD (resembling RBBB, but without S wave in leads I and aVL). One hundred ninety-two consecutive patients undergoing CRT implantation were divided electrocardiographically into 3 groups: left bundle branch block (LBBB), right bundle branch block (RBBB), and nonspecific intraventricular conduction delay ( IVCD). The purpose of this study was to assess the impact of Q-LV interval on ECG configuration. Pastore, Gianni Maines, Massimiliano Marcantoni, Lina Zanon, Francesco Noventa, Franco Corbucci, Giorgio Baracca, Enrico Aggio, Silvio Picariello, Claudio Lanza, Daniela Rigatelli, Gianluca Carraro, Mauro Roncon, Loris Barold, S SergeĮstimating left ventricular electrical delay (Q-LV) from a 12-lead ECG may be important in evaluating cardiac resynchronization therapy (CRT). ECG parameters predict left ventricular conduction delay in patients with left ventricular dysfunction. Without the first line, val would be undefined. Val=param1 // param1 passed via -D on cmd-line If you want to assign the -D variable to another variable, the -D variable MUST be initialized in the main. Unlike normal OpenSCAD assignments, these assignments don't define variables, but constants, which cannot be changed inside the program, and can thus be used to overwrite values defined in the program at export time. Each occurrence of -D must be followed by an assignment. In order to pre-define variables, use the -D option. This is done by adding '-render' as an option. For some situations it may be desirable to output the full render, with CGAL. png output uses Preview mode (f5) with OpenCSG. png dimensions and -projection chooses orthogonal or perspective, as in the GUI.īy default, cmdline. The second camera type is a 'vector' camera, with an 'eye' camera location vector and a 'lookat' center vector. The first camera type is a 'gimbal' camera that uses Euler angles, translation, and a camera distance, like OpenSCAD's GUI viewport display at the bottom of the OpenSCAD window. There are two types of cameras available for the generation of images. Multiple output files are not supported, so using this option you cannot also obtain the model that would have normally been generated.Ĭamera and image output įor 2013.05 , the option to output a. echo causes openscad to produce a text file containing error messages and the output of all echo() calls in filename as they would appear in the console window visible in the GUI. If the option -d is given in addition to an export command, all files accessed while building the mesh are written in the argument of -d in the syntax of a Makefile.įor at least 2015.03-2 , specifying the extension. Some versions use -s/-d/-o to determine the output file format instead check with "openscad -help". When called with the -o option, OpenSCAD does not start the GUI, but executes the given file and exports to the output_file in a format depending on the extension (. The usage on OpenSCAD version 2011.09.30 (now deprecated) was: [ -camera=translatex,y,z,rotx,y,z,dist | \ Solarized | Tomorrow | Tomorrow 2 | Tomorrow Off, amf, 3mf, csg, dxf, svg, png, echo, ast, debug arg special debug info - specify 'all' or a set of check-parameter-ranges arg =true/false, configure the parameter range check check-parameters arg =true/false, configure the parameter check for q quiet mode (don't print anything *except* m arg make_cmd -runs make_cmd file if file is missing d arg deps_file -generate a dependency file for make Solarized | Tomorrow | Tomorrow Night | Monotone Starnight | BeforeDawn | Nature | DeepOcean | colorscheme arg =colorscheme: *Cornfield | Metallic | Sunset | summary-file arg output summary information in JSON format to the summary arg enable additional render summary and statistics: csglimit arg =n -stop rendering at n CSG elements when projection arg =(o)rtho or (p)erspective when exporting png view arg =view options: axes | crosshairs | edges | render arg for full geometry evaluation when exporting png imgsize arg =width,height of exported png autocenter adjust camera to look at object's center camera arg camera parameters when exporting png: info print information about the build process Vertex-object-renderers-prealloc | textmetrics enable arg enable experimental features (specify 'all' for Off, wrl, amf, 3mf, csg, dxf, svg, pdf, png,Įcho, ast, term, nef3, nefdbg (May be used GUI, the file extension specifies the type: stl, o arg output specified file instead of running the Ascii export is theĬurrent stl default, but binary stl is plannedĪs the future default so asciistl should beĮxplicitly specified in scripts when needed. export-format arg overrides format of exported scad file whenĮxport, specify 'asciistl', and for binary stlĮxport, specify 'binstl'. OpenSCAD can not only be used as a GUI, but also handles command line arguments. scad files in a folderĬommand line usage Do not accuse players of cheating, use Bethesda's official support pages. Do not ask users to go after other players in game. exe files, pirated mods, pirated keys, third party market resellers, game crashing cheats, duplication exploits, etc. This includes but is not limited to: torrents, free full-game downloads. No promotion or enabling of pirated content and game exploits. Only upon moderator verification can you post it. If you have evidence, you are welcome to submit it, in confidence, to the unaffiliated moderators for verification. Second-hand information or word of mouth does not constitute as evidence. Avoid the use of trailing ellipsis.ĭo not post rumors or leaks without actual evidence. If you're posting a question, put it in the title and give further information inside. If the average user has to click on your post to understand the context, then it is not descriptive enough. Use descriptive titles when submitting a post. More than 1/10 of your posts or comments being self-promotional is spamming. Always follow Reddit guidelines for self-promotion when sharing your own content. Absolutely no harassment, witchhunting, sexism, racism or hate speech will be tolerated.ĭo not spam. Keep it civil, do not make personal attacks to other users, even if they initiated it. Comments are fine.įollow proper Reddiquette when submitting and commenting. This is not limited to image macros, it also applies to popular trends of any kind. Use spoiler tags when commenting sensitive information. Before you ask, please read this guide to returning to the game and/or if it's worth buying.ĭo not post spoilers in titles, period. Complete Fix guide for all Fallout GamesĪll posts must be from, directly reference or talk about something to do with Fallout 76. Mystery House 's success led the Williams to create the Hi-Res Adventures series, and note the game as Hi-Res Adventure #1. Applying graphics to an adventure game, however, was unprecedented as previous story-based adventure games were entirely text-based. Though the game is often considered the first adventure game to use graphics, dungeon crawl role-playing video games had already been using graphics prior to its release. GamePro named Mystery House the 51st most important game of all time in 2007, for introducing a visual component to adventure games and for featuring graphics at a time when most computer games did not. Mark Marlow reviewed Mission: Asteroid, Mystery House, and The Wizard and the Princess for Computer Gaming World, and stated that " Mystery House is considerably more difficult and provides many traps for the unwary in a wonderfully Victorian setting." Ĭomputer Gaming World in 1996 ranked it fourth on the magazine's list of the most innovative computer games. Including its 1982 rerelease through the SierraVenture line, 80,000 units were eventually sold worldwide, making it one of the best-selling computer games at the time. To the Williams's surprise, what Roberta had initially considered a hobby project sold more than 10,000 copies through mail-order. The couple took out an advertisement in Micro magazine as On-Line Systems, and mass-produced Ziploc bags containing a floppy disk and a sheet of instructions, to be sold at US$24.95 (equivalent to $82.05 in 2021). The game's code was completed in only a few days, and was finished on May 5, 1980. The resulting game is a text-based adventure with a depiction of the character's location displayed above the text. Ken found, however, that the resulting digital drawings were too large to fit into a 5¼-inch floppy disk, so he devised a way to convert the images into coordinates and instructions for the program to redraw the lines of the scenes rather than static images, as well as writing a better version of the VersaWriter scanning software. Roberta drew seventy scenes for the game. Ken suggested that adding graphical scenes to the otherwise text-based game would make it more interesting for players, and the couple bought a VersaWriter machine, on which users can trace over a line drawing and convert it to a digital drawing. Ken agreed and borrowed his brother's Apple II computer to write the game on. Recognizing that though she knew some programming, she needed someone else to code the game, she convinced her husband to help her. Īdvertisement from the June 1981 issue of The On-Line Letter for some of On-Line Systems' Hi-Res Adventure games, including Mystery House She was also inspired by the board game Clue, which helped to break her out from a linear structure to the game. Roberta decided that she could write her own, and conceived of the plot for Mystery House, taking inspiration from Agatha Christie's novel And Then There Were None. They began to search for something similar but found the market underdeveloped. He bought the game and introduced it to his wife, Roberta, and they both played through it. Looking through a catalog, he found a game called Colossal Cave Adventure. One day, he took a teletype terminal to his house to work on the development of an accounting program. The player must discover who it is or become the next victim.Īt the end of the 1970s, Ken Williams sought to set up a company for enterprise software for the market-dominating Apple II computer. Soon, dead bodies (of the other people) begin appearing and it is obvious there is a murderer on the loose in the house. Initially, the player has to search the house in order to find a hidden cache of jewels. Green, a surgeon Joe, a grave-digger Bill, a butcher Daisy, a cook. The mansion contains many interesting rooms and seven other people: Tom, a plumber Sam, a mechanic Sally, a seamstress Dr. The player is soon locked inside the house with no other option than to explore. The game starts near an abandoned Victorian mansion. |
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